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US 12,576,095 B2Granted
Systems and methods for accurate and repeatable delivery of active pharmaceutical ingredients
AssigneeTransport Authority, Inc.
InventorsWilliam Warren, Walter Lee Smith
Life of this patent
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Abstract
This present disclosure provides reliable methods and apparatus for delivering microdroplets containing an active pharmaceutical ingredient (API) to underlying substrates. A control system is provided to ensure that the API dosage is both accurate and repeatable.
Claims22
A method of limiting error rates in an API dosing system, the method comprising the steps of:
- delivering microdroplets of a liquid successively from at least one dosing head to a substrate along a path, wherein the liquid contains a quantity of active pharmaceutical ingredient;
- imaging the successively delivered microdroplets at a location between the at least one dosing head and the substrate along the path;
- and
- based on the imaging step, determining a total volume of the liquid that has been delivered to the substrate;
- comparing the total volume of liquid that has been delivered to the substrate to a predetermined volume of liquid to be delivered to the substrate;
- and
- discontinuing the delivering step when the total volume is within a selected tolerance, wherein the selected tolerance is within 10% of the predetermined volume of liquid.
4 more elements
Dependencies are inferred from the claim text.