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US 12,576,088 B2Granted
Methods for enhancing cytotoxic cancer therapy through inhibition of ATG4B
AssigneeNorthwestern University
InventorsShi-Yuan Cheng, Bo Hu, Tianzhi Huang
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Abstract
Disclosed are methods and compositions for treating cell proliferative diseases and disorders such as cancers. Particularly disclosed are methods and composition for treating cancers such as glioblastoma by administering a therapeutic agent that inhibits the biological activity of the autophagy related 4B cysteine peptidase (ATG4B) protein in conjunction with additional therapeutic agents or treatments.
Claims10
A method for treating cancer in a subject in need thereof, the method comprising (i) administering to the subject a therapeutic agent that inhibits the biological activity of ATG4B;
- and (ii) administering to the subject a therapeutic agents that inhibits the biological activity of mTOR, wherein the therapeutic agent that inhibits the biological activity of ATG4B comprises a compound referred to as NSC 185058, CAS 39122-38-8, N-pyridin-2-yl-pyridine-2-carbothioamide, having the following formula or a salt thereof:
- and
- wherein combination treatment with the therapeutic agent that inhibits the biological activity of ATG4B and the therapeutic agent that inhibits the biological activity of mTOR provides enhanced cancer cell death and survival of the subject than treatment with either therapeutic agent alone.
Dependencies are inferred from the claim text.