Combination comprising an ATP analog and an adenosine receptor antagonist or a nucleobase/nucleoside analog for the treatment of cancer
OwnerMichael Bruce Sawyer, Vijayalakshmi Damarajuinventors
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Abstract
A method for treating an ATP analog-induced side effect in a subject comprises administering an effective amount of an adenosine receptor antagonist to the subject. A method for treating cancer in a subject comprises administering a nucleobase and/or nucleoside prior to administering an ATP analog.
Claims17
A method for treating an ATP analog-induced side effect in a subject being treated for cancer, the method comprising administering an effective amount of an adenosine receptor antagonist to the subject, wherein the adenosine receptor antagonist is theophylline, aminophylline, 8-phenyltheophylline or combinations thereof,
- wherein the ATP analog is a tyrosine kinase inhibitor, the subject is being treated for cancer with the tyrosine kinase inhibitor, and wherein the tyrosine kinase inhibitor causes cytotoxic anticancer effect by inhibiting tyrosine kinase phosphorylation and wherein administering the effective amount of the adenosine receptor antagonist does not substantially affect the cytotoxic anticancer effect of the tyrosine kinase inhibitor;
- wherein the side effect is secretory diarrhea associated with activation of adenosine receptors by an accumulation of adenosine caused by inhibition of human equilibrative nucleoside transporters (hENTs) by the tyrosine kinase inhibitor and/or hand-foot syndrome associated with activation of adenosine receptors by an accumulation of adenosine caused by inhibition of human equilibrative nucleoside transporters (hENTs) by the tyrosine kinase inhibitor.
A method for treating secretory diarrhea in a subject being treated with a tyrosine kinase inhibitor in an amount effective to treat cancer and to inhibit human equilibrative nucleoside transporters (hENTs) and cause activation of adenosine receptors by an accumulation of adenosine, the activation of the adenosine receptors causing the secretory diarrhea as a side effect;
- the method comprising administering an adenosine receptor antagonist in an amount effective to block adenosine receptors and thereby treat the secretory diarrhea, wherein the adenosine receptor antagonist is theophylline, aminophylline, 8-phenyltheophylline or combinations thereof;
- wherein the tyrosine kinase inhibitor causes cytotoxic anticancer effect by inhibiting tyrosine kinase phosphorylation and wherein administering the adenosine receptor antagonist does not substantially affect the cytotoxic anticancer effect of the tyrosine kinase inhibitor.
Dependencies are inferred from the claim text.