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US 12,576,084 B2Granted
Methods for treating testicular and ovarian adrenal rest tumors
AssigneeSpruce Biosciences, Inc.
InventorsAlexis Howerton, Hal Gerber
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds and pharmaceutical compositions for the prevention and treatment of testicular adrenal rest tumors (TART) or ovarian adrenal rest tumors (OART).
Claims19
A method of changing a metabolic parameter of a subject having a testicular adrenal rest tumor (TART) or an ovarian adrenal rest tumor (OART), comprising administering to the subject in need thereof a small molecule corticotropin-releasing factor type-1 (CRF1) antagonist, or a pharmaceutically acceptable salt thereof, wherein the small molecule CRF1 antagonist is:
- or a pharmaceutically acceptable salt thereof, and
- wherein the metabolic parameter comprises fasting glucose, HbA1c level, insulin sensitivity, or a lipid profile, or a combination thereof.
Dependencies are inferred from the claim text.