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US 12,576,079 B2Granted
Methods for treating cholestasis
AssigneeMirum Pharmaceuticals, Inc.
InventorsThomas Jaecklin, Alejandro Dorenbaum
Life of this patent
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Abstract
Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 μg/kg/day.
Claims15
A method for treating cholestatic liver disease in a subject comprising administering to the subject an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI), wherein the ASBTI is
- (volixibat), and wherein the volixibat administered in an amount of about 40 mg/day to about 200 mg/day, wherein the administration of the ASBTI reduces sBA concentration by at least 30% by 18 weeks.
Dependencies are inferred from the claim text.