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US 12,576,073 B2Granted
Antiarrhythmic formulation
AssigneeInCarda Therapeutics, Inc.
InventorsMichael Laird Hurrey, Luiz Belardinelli, Prashanti Madhavapeddi, Carlos Schuler
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Abstract
Pharmaceutical compositions comprising an antiarrhythmic agent for treatment of a heart condition via inhalation. Methods of treating a heart condition include administering by inhalation an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof. Nebulized drug product and kits are also disclosed.
Claims21
A method of treating a subject suffering from a heart condition, comprising:
- administering to said subject via inhalation a pharmaceutical composition, wherein said pharmaceutical composition comprises a cyclodextrin, acetic acid, and a therapeutically effective amount of a flecainide acetate, wherein said pharmaceutical composition is in the form of a liquid solution that comprises said flecainide acetate at a concentration from 60 mg/mL to 120 mg/mL, said cyclodextrin at a concentration of from 5% (w/v) to 50% (w/v) of said liquid solution, and a pH range from 5.5 to 6.5 when measured at room temperature.
A method of manufacturing a pharmaceutical composition, wherein the method comprises combining:
- (a) water;
- (b) acetic acid:
- (c) a pharmaceutically acceptable flecainide acetate;
- and
- (d) a cyclodextrin,
- thereby providing said pharmaceutical composition,
- wherein said pharmaceutical composition is in the form of a liquid solution that comprises said flecainide acetate at a concentration from 60 mg/mL to 120 mg/mL, said cyclodextrin at a concentration of from 5% (w/v) to 50% (w/v) of said liquid solution, and a pH range from 5.5 to 6.5 when measured at room temperature.
4 more elements
Dependencies are inferred from the claim text.