Compositions containing amino acids and methods of using such compositions for treating sarcopenia
AssigneeSociete des Produits Nestle S.A.
InventorsClaudia Roessle, Denis Breuille, Eugenia Migliavacca, Jerome Feige
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Abstract
A composition contains one or more aromatic amino acids and optionally vitamin B6. The composition may be an oral nutritional composition, for example a nutritional supplement, an oral nutritional supplement, a food product, a food for special medical purpose (FSMP). The composition can be in a form of a powder, a powdered stick, a capsule or a solution. The composition can be administered to an individual in need thereof orally or intravenously for preventing and/or treating sarcopenia, a loss of and/or improving skeletal muscle mass, lean muscle mass, skeletal muscle strength and/or skeletal muscle function.
Claims12
A method for preventing and/or treating sarcopenia and/or for improving skeletal muscle mass, skeletal muscle lean mass, skeletal muscle strength and/or skeletal muscle function in an individual in need thereof, the method comprising administering to the individual a unit dosage form of a composition comprising (i) one or more aromatic amino acids (AAAs) in a therapeutically effective amount and (ii) vitamin B6 in an amount of 1.0-12.0 mg/300.0 Kcal of energy of the composition,
- wherein the one or more aromatic amino acids are a combination of aromatic amino acids (AAAs) of Trp, Phe, Tyr and His;
- and daily dosages of total AAAs, the Trp, the Tyr, the Phe and the His are 3.0-20.0 g/day, 0.2-3.0 g/day, 1.5-8.8 g/day, 1.5-10.7 g/day and 0.9-5.6 g/day respectively.
A method of preventing or treating sarcopenia in an individual in need thereof, the method comprising administering a composition containing (i) a therapeutically effective amount of one or more aromatic amino acids and (ii) vitamin B6 in an amount of 1.0-12.0 mg/300.0 Kcal of energy of the composition,
- wherein the one or more aromatic amino acids are a combination of aromatic amino acids (AAAs) of Trp, Phe, Tyr and His;
- and daily dosages of total AAAs, the Trp, the Tyr, the Phe and the His are 3.0-20.0 g/day, 0.2-3.0 g/day, 1.5-8.8 g/day, 1.5-10.7 g/day and 0.9-5.6 g/day respectively.
A method for restoring and/or correcting deficiencies of nutrients in a subject having sarcopenia or at risk thereof, the method comprising administering a composition containing (i) a therapeutically effective amount of one or more aromatic amino acids and (ii) vitamin B6 in an amount of 1.0-12.0 mg/300.0 Kcal of energy of the composition,
- wherein the one or more aromatic amino acids are a combination of aromatic amino acids (AAAs) of Trp, Phe, Tyr and His;
- and daily dosages of total AAAs, the Trp, the Tyr, the Phe and the His are 3.0-20.0 g/day, 0.2-3.0 g/day, 1.5-8.8 g/day, 1.5-10.7 g/day and 0.9-5.6 g/day respectively.
Dependencies are inferred from the claim text.