Methods and compositions for treatment of inflammatory disease
OwnerMikhail S. Shchepinovinventor
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Abstract
Disclosed herein are compositions and methods for controlling chronic inflammation in a patient. The compositions and methods employ D6-arachidonic acid or an ester thereof (D6-AA) as an anti-inflammatory agent that provides for significant reduction in inflammatory processes. In addition. The compositions of deuterated arachidonic acid or ester thereof comprise, on average, at least about 80% of the hydrogen atoms at each of the bis-allylic sites having been replaced by deuterium atoms and, on average, no more than about 30% of the hydrogen atoms at the mono-allylic sites having been replaced by deuterium atoms.
Claims6
A method for controlling chronic inflammation in a patient comprising administering an effective amount of arachidonic acid or ester thereof to the patient in need thereof wherein the arachidonic acid or ester thereof that, on average, has at least about 80% of hydrogen atoms at bis-allylic sites replaced by deuterium atoms and that, on average, has no more than about 35% of the hydrogen atoms at mono-allylic sites replaced by deuterium atoms.
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and from about 100 mg to about 2,000 mg of an arachidonic acid or an ester thereof that, on average, has at least about 80% of hydrogen atoms at bis-allylic sites replaced by deuterium atoms and, on average, has no more than about 35% of the hydrogen atoms at mono-allylic sites replaced by deuterium atoms.
Dependencies are inferred from the claim text.