Methods for decreasing injuries associated with intraoperative hypotension
AssigneeThe United States Government as represented by the Department of Veterans Affairs
InventorGuy Weinberg
Life of this patent
Estimating the term…
Abstract
The present disclosure provides methods for decreasing injuries associated with intraoperative hypotension by intravenously administering to a subject a therapeutically effective amount of a fat emulsion, following a period of intraoperative hypotension and after the subject's mean arterial blood pressure has recovered. The disclosure also provides methods for preventing injuries associated with intraoperative hypotension, particularly for surgical candidates that have an increased risk for intraoperative hypotension. Non-limiting examples of injuries contemplated herein include myocardial injury, myocardial infarction, and acute kidney injury.
Claims15
A method for preventing myocardial injury or acute kidney injury in a subject following intraoperative hypotension, the method comprising intravenously administering to the subject a therapeutically effective amount of a fat emulsion after the subject's mean arterial pressure (MAP) is recovered to greater than or equal to 66 mm Hg,
- wherein administration of the therapeutically effective amount of the fat emulsion results in at least a 10% decrease in a marker of myocardial injury or acute kidney injury as compared to a control group that did not receive the fat emulsion,
- wherein the marker of myocardial injury is cardiac troponin or heart-type fatty acid binding protein, or wherein the marker of acute kidney injury is creatinine or lipocalin-2.
A method for preventing postoperative mortality in a subject following intraoperative hypotension, the method comprising intravenously administering to the subject a therapeutically effective amount of a fat emulsion after the subject's mean arterial pressure (MAP) is recovered to greater than or equal to 66 mm Hg, wherein mortality is reduced by at least 10% as compared to a control group that did not receive the fat emulsion.
A method for preventing 30-day or one year mortality following general anesthesia for a subject who has intraoperative hypotension while under general anesthesia, the method comprising intravenously administering to a subject a therapeutically effective amount of a fat emulsion after the subject has received one or more reperfusion therapies to restore mean arterial pressure (MAP) to 66 mm Hg or higher, wherein the subject is not in shock at the time the fat emulsion is administered.
Dependencies are inferred from the claim text.