Metformin inhalation powder aerosol for treating idiopathic pulmonary fibrosis and preparation method thereof

A preparation method of a metformin inhalation powder aerosol for treating idiopathic pulmonary fibrosis, comprising following steps:

• S1, pretreating a metformin raw material to obtain fine powder for later use;
• S2, passing the fine powder obtained in the S1 through a screen with a mesh size of 100-1000 microns by a pendular granulator at a rotating speed of 200 revolutions per minute to obtain soft particle clusters;
• S3, pre-spheronizing the particle clusters in the S2 for 10-300 seconds at a vibration frequency of 100-300 hertz to obtain particle clusters;
• S4, rolling the particle clusters obtained in the S3 on a granulating pan, wherein a rotation speed of the granulating pan is 5-90 revolutions per minute, an angle between the granulating pan and a horizontal plane is 0-80°, and spheronizing is carried out for 1-30 minutes to obtain spherical particle clusters;
• and
• S5, filling the spherical particle clusters obtained in the S4 into capsules by a capsule filling machine to obtain the metformin inhalation powder aerosol.