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US 12,576,051 B2Granted
Methods and composition for treating respiratory obstructive diseases
AssigneeThe Regents of the University of California
InventorsRanjan Dohil, Guillermo Flores-Delgado
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Abstract
The disclosure provides for methods and compositions for treating respiratory obstructive diseases.
Claims19
A method for the treatment of a respiratory obstructive disease in a subject in need thereof, comprising administering to the subject a pharmaceutically acceptable composition comprising an effective amount of a compound having the structure of Formula II:
- or a pharmaceutically acceptable salt, or solvate thereof,
- wherein:
- R5-R12 are independently selected from H or D, and wherein at least one of R5-R12 is D, wherein the compound thins and/or loosens the mucus in a respiratory tract wherein the obstructive disease is selected from cystic fibrosis, chronic obstructive pulmonary disease and asthma.
A nebulizer or inhaler comprising a compound of Formula II:
- or a pharmaceutically acceptable salt, or solvate thereof,
- wherein:
- R5-R12 are independently selected from H or D wherein at least one of R5-R12 is D.
Dependencies are inferred from the claim text.