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US 12,576,048 B2Granted
Anti-cancer activity of adamantane derivatives
AssigneeThe Regents of the University of California
InventorAndrew Sharabi
Life of this patent
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Abstract
Provided herein are methods for treating cancer comprising administering to a subject in need thereof an adamantane derivative, or a pharmaceutically acceptable salt thereof, such as rimantadine or amantadine. In some embodiments, the adamantane derivative is PEGylated.
Claims17
A method of treating a head and neck squamous cell carcinoma in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of rimantadine, or a pharmaceutically acceptable salt thereof.
A method of treating a head and neck squamous cell carcinoma in a subject, the method comprising:
- contacting a cell of said head and neck squamous cell carcinoma in the subject, said cell comprising an HPV E5 protein, with
- a therapeutically effective amount of rimantadine, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.