Lipid-polymer compositions and methods of use
AssigneeMax Biology Co. Ltd.
InventorsSunil Shah, Sean Ngu, Afzal R. Mohammed
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Abstract
The present invention features new lipid-polymer composite particles that are useful for the formulation of bioactive agents for administration to a subject. The nanoparticles include a block copolymer, a lipid, e.g., phospholipid, and a sterol. The formulations of a bioactive agent (e.g., a therapeutic agent, a nutraceutical agent, or a recreational agent) described herein provide for easier loading of lipid-polymer composite particles with higher drug loading capacity, increased stability of the formulations, and lower surface tension of water, which allows for lipid coating and entrapment.
Claims17
A composition comprising a plurality of lipid-polymer composite particles encapsulating a bioactive agent, wherein the lipid-polymer composite particles comprise a poloxamer, a lipid selected from the group consisting of a neutral lipid, a cationic lipid, and an anionic lipid, and a sterol, wherein the plurality of lipid-polymer composite particles has a mean particle size of between 10 and 1000 nanometers, wherein the lipid-polymer composite particles comprise unilamellar or multilamellar structures encapsulating one or more micelles, and wherein the weight ratio of the poloxamer to the bioactive agent is between 2 and 15, and wherein the composition lacks an organic solvent to solubilize the bioactive agent.
Dependencies are inferred from the claim text.