Spray-dried formulation of a pyridazinone TRPC5 inhibitor
AssigneeGfb (Abc), LLC
InventorsDonald T. Corson, Elizabeth Chu Kwong, Thomas E. Stumpfig, Daniel T. Smithey, Erica B. Schlesinger
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Abstract
Disclosed are spray-dried formulations of 4-chloro-5-(4-(4-fluoro-2-(trifluoromethyl)phenoxy)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)pyridazin-3(2H)-one, methods and compositions for making the same, and solid dosage forms comprising the same. The dosage forms described herein are useful in methods of treating kidney diseases or neuropathies associated with diseases or conditions, and in methods of treating pain, anxiety, or depression.
Claims29
A composition for manufacturing a spray-dried dispersion, the composition comprising 4-chloro-5-(4-(4-fluoro-2-(trifluoromethyl)phenoxy)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)pyridazin-3(2H)-one;
- a solvent;
- and a polymer;
- wherein the polymer is dissolved in the solvent;
- and wherein the polymer is selected from the group consisting of hypromellose acetate succinate, a polymethacrylate copolymer Eudragit, and a combination thereof.
A spray-dried dispersion comprising 4-chloro-5-(4-(4-fluoro-2-(trifluoromethyl)phenoxy)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)pyridazin-3(2H)-one;
- and a polymer;
- wherein the polymer is selected from the group consisting of hypromellose acetate succinate, a polymethacrylate copolymer, and a combination thereof.
Dependencies are inferred from the claim text.