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US 12,576,030 B2Granted
Compositions for delivery of codon-optimized mRNA
AssigneeTranslate Bio, Inc.
InventorsJohn Androsavich, Lianne Boeglin, Shraddha Sharma, Gang Sun, Neha Kaushal, Shrirang Karve
Life of this patent
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Abstract
The present invention provides, among other things, improved pharmaceutical compositions comprising codon-optimized mRNA encoding a peptide or polypeptide encapsulated in a lipid nanoparticle comprising one or more of the cationic lipids that are particularly effective for pulmonary delivery.
Claims23
A composition comprising an mRNA encapsulated in a lipid nanoparticle, wherein:
- the lipid nanoparticle comprises a cationic lipid that is GL-TES-SA-DMP-E18-2, GL-TES-SA-DME-E18-2, TL1-01D-DMA, TL1-04D-DMA, SY-3-E14-DMAPr, TL1-10D-DMA, HEP-E3-E10, or HEP-E4-E10;
- and
- the mRNA does not encode a cystic fibrosis transmembrane conductance regulator (CFTR) protein or a dynein axonemal intermediate chain 1 (DNAI1) protein.
Dependencies are inferred from the claim text.