Pharmaceutical or nutraceutical self-emulsifying solid dispersion composition
AssigneeHuana Global Biotech Co., Ltd.
InventorsLiang-Shun Wang, Chih-Chiang Yang, Yu-Hsuan Lin, Ping-Chuan Fu
Life of this patent
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Abstract
The present invention pertains to a pharmaceutical, or nutraceutical, “self-emulsifying solid dispersion” composition for oral administration which contains (a) a drug or a nutraceutical that is water-insoluble or poorly water-soluble; (b) at least one surfactant; (c) one carrier selected from the group consisting of silicic acid, a silicate, or any combination thereof; and (d) at least one carbohydrate filler.
Claims2
A method for increasing bioaccessibility and hepatic uptake of a tocotrienol in a subject, comprising:
- administering orally to the subject a composition consisting of (a) a tocotrienol, (b) polysorbate 80 as a surfactant, (c) silicon dioxide (SiO2) as a carrier, (d) isomalt as a carbohydrate filler, and (e) polyvinylpyrrolidone (PVP) K30 as a binder, wherein the polysorbate 80 as the surfactant is present in a percentage by weight of 1% to 5%, the SiO2 as the carrier is present in a percentage by weight of 0.1%-20%, the isomalt as the carbohydrate filler is present in a percentage by weight of 40%-90%, and the PVP K30 as the binder is present in a percentage by weight of 3%, and wherein the composition is prepared by wet granulation;
- thereby increasing bioaccessibility and hepatic uptake of the tocotrienol in the subject.
A method for increasing bioaccessibility and hepatic uptake of a tocotrienol in a subject, comprising:
- administering orally to the subject a composition consisting of (a) a tocotrienol, (b) polysorbate 80 as a surfactant, (c) silicon dioxide (SiO2) as a carrier, (d) isomalt as a carbohydrate filler, (e) polyvinylpyrrolidone (PVP) K30 as a binder, and (f) a lubricant:
- wherein the polysorbate 80 as the surfactant is present in a percentage by weight of 1% to 5%, the SiO2 as the carrier is present in a percentage by weight of 0.1%-20%, the isomalt as the carbohydrate filler is present in a percentage by weight of 40%-90%, and the PVP K30 as the binder is present in a percentage by weight of 3%, and wherein the composition is prepared by wet granulation;
- thereby increasing bioaccessibility and hepatic uptake of the tocotrienol in the subject.
Dependencies are inferred from the claim text.