Compositions comprising Propionibacterium acnes bacteriophages for treating acne
AssigneePhi Therapeutics, Inc.
InventorsYug Varma, Nancy Van Prooyen
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Abstract
Provided herein are, inter alia, compositions, systems, and methods for preventing or treating acne. Included are compositions, combinations, systems, and methods comprising at least one Propionibacterium acnes bacteriophage, at least one anti-acne compound, and a pharmaceutically acceptable carrier. Also included are compositions, combinations, and systems comprising a Propionibacterium acnes bacteriophage and an enzyme. Methods for preventing or treating acne are also provided.
Claims18
A composition formulated for topical administration comprising:
- (a) a Propionibacterium bacteriophage, wherein the genome of the Propionibacterium bacteriophage comprises a nucleotide sequence that is at least 90%, 95%, 96%, 97%, 98%, or 99% identical to the nucleotide sequence of SEQ ID NO:
- 1;
- (b) a dispersin enzyme;
- and
- (c) a probiotic bacteria comprising a strain of Propionibacterium acnes (P. acnes), wherein the P. acnes strain comprises 16S rDNA sequences comprising SEQ ID NO:
- 3 and SEQ ID NO:
- 4.
A method for treating acne in a subject in need thereof, the method comprising:
- (a) topically administering a therapeutically effective amount of a composition comprising a dispersin enzyme to a region of the subject's skin having the acne;
- (b) topically administering a therapeutically effective amount of a composition comprising a Propionibacterium bacteriophage to the region of the subject's skin having the acne, wherein the genome of the Propionibacterium bacteriophage comprises a nucleotide sequence that is at least 90%, 95%, 96%, 97%, 98%, or 99% identical to the nucleotide sequence of SEQ ID NO:
- 1;
- and
- (c) topically administering a therapeutically effective amount of a composition comprising a strain of Propionibacterium acnes (P. acnes), wherein the P. acnes strain comprises 16S rDNA sequences comprising SEQ ID NO:
- 3 and SEQ ID NO:
- 4 to the region of the subject's skin having the acne.
Dependencies are inferred from the claim text.