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US 12,575,784 B2Granted
Devices and methods for the detection of intraoral acid exposure
AssigneeKing's College London
InventorsGarrit Koller, Saoirse O'Toole, Timothy Watson, Francesco Mannocci, David Bartlett
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Abstract
The present invention provides non-invasive intraoral devices and methods for the detection of intraoral acid exposure, methods of making said devices, and their use in the diagnosis of disorders such as gastro-oesophageal reflux disease (GORD).
Claims25
An oral acid-sensing device configured for fixation to a surface of a tooth within the oral cavity of a subject, the device comprising:
- a top erodible layer comprising an erodible material;
- and an indicator;
- wherein the erodible material comprises a calcium phosphate composition;
- wherein the erodible material has a dissolution rate in an acidic medium which is at least 10 times greater than the dissolution rate of natural dental enamel in the same acidic medium;
- and/or
- wherein the erodible layer has a rate of color change due to dissolution of the erodible material which is greater than the rate of color change produced in natural dental enamel by the same acidic medium;
- and
- wherein erosion of the top erodible layer provides a visual response from the indicator.
5 more elements
Dependencies are inferred from the claim text.