Non-invasive venous waveform analysis for evaluating a subject

A computing device comprising:

• one or more processors;
• a piezoelectric sensor;
• a user interface;
• and
• a computer readable medium storing instructions that, when executed by the one or more processors, cause the computing device to perform functions comprising:
• (a) generating, via the piezoelectric sensor, a signal representing vibrations originating from a blood vessel of a subject;
• (b) decomposing the signal into one or more first intrinsic oscillatory modes and one or more second intrinsic oscillatory modes using a Hilbert-Huang transform or an ensemble empirical mode decomposition, wherein the one or more first intrinsic oscillatory modes have respective oscillation frequencies that are less than respective oscillation frequencies of the one or more second intrinsic oscillatory modes;
• (c) using the one or more second intrinsic oscillatory modes to determine one or more first mechanical properties of the blood vessel or a tissue adjacent to the blood vessel before a treatment is performed, wherein using the one or more second intrinsic oscillatory modes comprises determining a Q-factor of the one or more second intrinsic oscillatory modes;
• (d) determining that the one or more first mechanical properties indicate arteriosclerosis, edema, and/or elevated risk of aneurysm;
• (e) providing, via the user interface, an indication that the one or more first mechanical properties indicate arteriosclerosis, edema, and/or elevated risk of aneurysm;
• (f) performing steps (a)-(c) after the treatment is performed to determine one or more second mechanical properties of the blood vessel or the tissue adjacent to the blood vessel;
• and
• (g) quantifying a change in a state of the blood vessel over time using the one or more first mechanical properties and the one or more second mechanical properties.

A non-transitory computer readable medium storing instructions that, when executed by a computing device, cause the computing device to perform functions comprising:

• (a) generating, via a piezoelectric sensor, a signal representing vibrations originating from a blood vessel of a subject;
• (b) decomposing the signal into one or more first intrinsic oscillatory modes and one or more second intrinsic oscillatory modes using a Hilbert-Huang transform or an ensemble empirical mode decomposition, wherein the one or more first intrinsic oscillatory modes have respective oscillation frequencies that are less than respective oscillation frequencies of the one or more second intrinsic oscillatory modes;
• (c) using the one or more second intrinsic oscillatory modes to determine one or more first mechanical properties of the blood vessel or a tissue adjacent to the blood vessel before a treatment is performed, wherein using the one or more second intrinsic oscillatory modes comprises determining a Q-factor of the one or more second intrinsic oscillatory modes;
• (d) determining that the one or more first mechanical properties indicate arteriosclerosis, edema, and/or elevated risk of aneurysm;
• (e) providing, via a user interface of the computing device, an indication that the one or more first mechanical properties indicate arteriosclerosis, edema, and/or elevated risk of aneurysm;
• (f) performing steps (a)-(c) after the treatment is performed to determine one or more second mechanical properties of the blood vessel or the tissue adjacent to the blood vessel;
• and
• (g) quantifying a change in a state of the blood vessel over time using the one or more first mechanical properties and the one or more second mechanical properties.