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US 12,571,812 B2Granted
Parallel cell processing method and facility
AssigneeGlobal Life Sciences Solutions USA LLC
InventorsFirman Ghouze, Philip Vanek
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Abstract
The present invention provides improved methods, facilities and systems for parallel processing of biological cellular samples in an efficient and scalable manner. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. The methods, facilities and systems of the invention find particular utility in processing patient samples for use in cell therapy.
Claims7
A method for parallel processing of a plurality of biological cellular samples comprising:
- i) transferring a plurality of cellular samples (S1 to Sn) to a first processing unit (U1) comprising a plurality of processing stations (P1/1 to P1/n);
- ii) processing in parallel said plurality of the cellular samples (S1 to Sn) on the processing stations (P1/1 to P1/n) to produce a first plurality of processed cellular samples (S1/1 to Sn/1);
- iii) transferring said first plurality of processed cellular samples (S1/1 to Sn/1) to a second processing unit (U2) containing a plurality of processing stations (P2/1 to P2/n);
- and
- v) processing in parallel each of said first plurality of processed cellular samples (S1/1 to Sn/1) on a processing station (P2/1 to P2/n) to produce a second plurality of processed cellular samples (S1/2 to Sn/2);
- wherein in step ii) the processing of the plurality cellular samples (S1 to Sn) on the processing stations (P1/1 to P1/n) of the first processing unit (U1) comprises varying at least one processing instruction between at least two of the processing stations (P1/1 to P1/n), wherein each of said plurality of processing stations (P1/1 to P1/n) performs a process which is the same type of process, wherein the process is selected from the group consisting of cell isolation, cell concentration, cell culture, cell expansion, cell transduction, and cell formulation.
3 more elements
Dependencies are inferred from the claim text.