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AssigneeThe Regents of the University of California
InventorsTonya L. Kuhl, Deepshika Shamraj Gilbile
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Systems and methods for producing and using polymer based fixed targets for hydrated, room temperature, high-throughput serial protein crystallography with minimal background and minimal sample consumption are provided. The fixed targets can also be used with non-protein samples such as nanoparticle inorganic crystals. The targets maintain full crystal hydration that allows for on-chip crystallization as well as maintaining long term stability of the sample within the chip. The target chips are optimized to minimize background by controlling the sample thickness in the beam to match crystal size, enabling fast raster scanning at lower fidelity and high hit rates that facilitate dynamic measurements. The targets provide an inexpensive, flexible substrate for on-chip, micro-batch or vapor diffusion crystallization facilitated by polymer brushes for sample concentration and surface initiated crystallization thereby eliminating damaging crystal sample transfer.
A fixed target apparatus for serial x-ray crystallography, the apparatus comprising:
A fixed target apparatus for serial x-ray crystallography, the apparatus comprising:
A fixed target apparatus for serial x-ray crystallography, the apparatus comprising:
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