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US 12,571,709 B2Granted
Device for electrokinetic focusing and electrical detection of particles and chemical species facilitated by a porous electrode
AssigneeIowa State University Research Foundation, Inc.
InventorsRobbyn K. Anand, Beatrise Berzina
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Abstract
High-throughput microfluidic devices comprising one or more fluidic microchannels each with at least one flow-through 3D structure comprising a 3D electrode, or alternatively a 3D permselective structure, and optional secondary bead bed(s) are disclosed. Such devices can be used for counter-flow focusing of charged species via ion concentration polarization and in situ quantification of electrokinetically enriched charged species from an ionically conductive solution by both optical and electrical detection.
Claims19
A microfluidic device comprising:
- one or more fluidic microchannels, wherein the one or more fluidic microchannels are connected to at least one inlet and at least one outlet,
- at least one flow-through 3D electrode within the one or more fluidic microchannel wherein the 3D electrode comprises an electrode and microbeads, wherein the microbeads are contained within a primary bead bed which extends at least a portion of the width and length of the microchannel as defined by a bead bed structure within the microchannel, and
- at least one bead bed assay comprising a secondary bed of microbeads within the one or more fluidic microchannel, wherein the microbeads are contained within the secondary bead bed defined by a bead bed structure within the one or more fluidic microchannel, and wherein the microbeads in the secondary bead bed are magnetic, comprise conductive or semi-conductive material, and/or are bioconjugated,
- wherein at least one of the inlet(s) and/or at least one of the outlet(s) are connected to an electrode.
1 more element
Dependencies are inferred from the claim text.