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US 12,571,052 B2Granted
Immunomodulatory RNA
AssigneeThe Trustees of the University of Pennsylvania
InventorsAndy J. Minn, Barzin Y. Nabet, Lexus R. Johnson
Life of this patent
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Abstract
The present invention includes methods for detecting cancer in a subject and measuring the effectiveness of a cancer treatment. In certain embodiments, the invention includes assessing the level of unshielded RN7SL1 RNA in a sample from a subject.
Claims5
A method of treating a cancer in a subject in need thereof, the method comprising, administering to the subject a therapeutically effective amount of an unshielded RN7SL1 RNA in combination with a CSF1R inhibitor and one or more immune checkpoint blocker(s),
- wherein the one or more immune checkpoint blocker(s) comprise an anti-PD-1 antibody and/or an anti-CTLA-4 antibody, and
- wherein the cancer is melanoma or pancreatic adenocarcinoma.
Dependencies are inferred from the claim text.