Composition for diagnosis or treatment of a condition associated with increased activity of EIF4E comprising an EIF4E inhibitor

A method for prevention, alleviation, or treatment of a disease associated with an increased activity or an increased expression level of eukaryotic translation initiation factor 4E (eIF4E) in brain neuronal cells, comprising administering an eIF4E inhibitor to a subject in need thereof,

• wherein the eIF4E inhibitor is one or more antisense oligonucleotides,
• wherein the one or more antisense oligonucleotides hybridizes to a nucleotide sequence encoding eIF4E,
• wherein each of the one or more antisense oligonucleotides consists of a nucleotide sequence selected from the group consisting of SEQ ID NOs:
• 16, 27, 35, and 182,
• wherein the disease is Focal Malformations of Cortical Development (FMCD) caused by mTOR hyperactivation, and
• wherein nucleotides at positions 1 to 5 and 16 to 20 in the 5′ to 3′ direction of each of the one or more antisense oligonucleotides include a 2′-O-methoxyethyl ribose, nucleotides at positions 6 to 15 include a 2-deoxyribose, all internucleoside linkages are phosphorothioate bonds, and all cytosine residues are 5-methylcytosine.