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AssigneesKnc Laboratories Co., Ltd., Aichi Medical University, National University Corporation Shiga University of Medical Science
InventorsGen Sobue, Kentaro Sahashi, Shinsuke Ishigaki, Kuniyuki Endo, Tsuyoshi Fujihara, Masahiro Neya, Seiji Matsuda
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The present invention provides a tau exon 10 skipping-promoting antisense oligonucleotide containing at least one 2′-O, 4′-C-ethylene-bridged nucleic acid, and a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a region consisting of the nucleotide sequence shown in SEQ ID NO: 44 in exon 10 of a tau mRNA precursor. In addition, the present invention provides a tau exon 10 skipping-suppressing antisense oligonucleotide containing at least one 2′-O, 4′-C-ethylene-bridged nucleic acid, and a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a region consisting of the nucleotide sequence shown in SEQ ID NO: 45 in intron 10 of a tau mRNA precursor.
A tau exon 10 skipping-promoting antisense oligonucleotide consisting of a sequence selected from the group consisting of SEQ ID NOs:
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