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US 12,570,758 B2Granted
Chimeric antigen receptors targeting CD33
AssigneeFred Hutchinson Cancer Center
InventorsCameron J. Turtle, Roland B. Walter, George S. Laszlo, Salvatore Fiorenza
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Abstract
Chimeric antigen receptors (CARs) with binding domains derived from a novel suite of human CD33-binding antibodies are described. The CARs include optimized short and intermediate spacer regions. The current disclosure also provides methods of cell expansion/activation processes utilizing IL-2, IL-7, IL-15, and/or IL-21 that improve cellular proliferation and cell lysis of the CARs as described.
Claims4
A genetic construct comprising:
- the sequence of SEQ ID NO:
- 50;
- SEQ ID NO:
- 51;
- SEQ ID NO:
- 202;
- SEQ ID NO:
- 46;
- SEQ ID NO:
- 47;
- SEQ ID NO:
- 200;
- SEQ ID NO:
- 48;
- SEQ ID NO:
- 49;
- SEQ ID NO:
- 201;
- or SEQ ID NO:
- 203.
17 more elements
Dependencies are inferred from the claim text.