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AssigneeImmuno-Biological Laboratories Co., Ltd.
InventorsMasahiro Tomita, Mamoru Shimizu, Shuzo Matsushita, Takeo Kuwata, Masahiro Michishita, Yasuhiro Yasutomi, Tomotaka Okamura
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The present inventors have conducted intensive studies on an antibody which controls HIV in an administration group with a high probability over a long period of time with one or several times of single-agent administration. As a result, the present inventors have surprisingly found that, when an SW-1C10 antibody, which is obtained by producing an antibody gene reported as 1C10 in silkworms, is singly administered only a few times, the viral load in the blood is suppressed to the detection limit or lower at an early stage in all of individuals to which the antibody has been administered, and moreover, the viral RNA load in the blood is maintained at the detection limit or lower for a long time of 12 weeks.
An IgG antibody that binds to HIV-1 comprising:
An expression cassette comprising any one of the polynucleotides selected from the following (i), (iii) and (v) which is functionally linked to and downstream of a silk gland-specific gene promoter:
An antibody produced by a transgenic silkworm comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.