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US 12,570,719 B2Granted
Chimeric antigen receptor comprising anti c-met antibody or antigen binding fragment thereof, and use thereof
AssigneeHelixmith Co., Ltd
InventorsJin-A Chae, Seung Shin Yu
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Abstract
The present invention relates to a chimeric antigen receptor comprising a c-Met binding domain, and a use thereof. The chimeric antigen receptor comprising a c-Met domain, of the present invention, can be effectively usable as an agent for treating various diseases associated with c-Met expression.
Claims16
A nucleic acid molecule coding for an anti-c-Met chimeric antigen receptor, comprising:
- a c-Met-binding domain, a transmembrane domain, and an intracellular signaling domain,
- wherein the c-Met-binding domain is an antibody or an antigen binding fragment thereof binding specifically to c-Met,
- wherein the antibody or the antigen binding fragment thereof comprises a heavy chain variable region (VH) consisting of the amino acid sequence of SEQ ID NO:
- 21;
- and a light chain variable region (VL) consisting of the amino acid sequence of SEQ ID NO:
- 22.
3 more elements
Dependencies are inferred from the claim text.