Back to results
US 12,570,716 B2Granted
Anti-dinitrophenol chimeric antigen receptors
AssigneeSeattle Children's Hospital
InventorsMichael C. Jensen, James F. Matthaei, Joseph K. Cheng
Life of this patent
Estimating the term…
Abstract
Embodiments provided herein include methods and compositions comprising anti-dinitrophenol chimeric antigen receptors (CARs). Some embodiments include nucleic acids encoding such CARs, polypeptides encoded by such nucleic acids, cells comprising such nucleic acids or polypeptides, and methods utilizing such cells. Some embodiments also include the use of dinitrophenol (DNP) and derivatives thereof.
Claims20
A chimeric antigen receptor (CAR) comprising:
- a ligand binding domain which specifically binds to a dinitrophenol (DNP) moiety, wherein the ligand binding domain comprises (i) an amino acid sequence having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:1, SEQ ID NO:7 or SEQ ID NO:12;
- or (ii) an amino acid sequence having at least 90% sequence identity to the amino acid sequence set forth in SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10 or SEQ ID NO:11;
- a spacer;
- a transmembrane domain;
- and
- an intracellular signaling domain.
3 more elements
Dependencies are inferred from the claim text.