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US 12,570,708 B2Granted
Recombinant proteins and their therapeutic uses
OwnerKeith Alan Charlton, Erik D'Hondtinventors
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Abstract
A recombinant protein expressing one or more human growth factors, tumor antigens, and/or receptors or epitopes thereof on or within an immunogenic expression creating a recombinant protein in which one or more epitopes are presented on the surface of the sequence in their natural configuration. The growth factor, tumor antigen, and/or receptor, sequence(s) may be expressed within the encoding sequence at appropriate internal positions or at the termini as single expressions or as two or more tandem repeats.
Claims9
A recombinant protein, comprising:
- an immunogenic polypeptide;
- and
- a polypeptide comprising Cys6, Cys14, Cys20, Cys31, and Cys33 of human Epidermal Growth Factor (SEQ ID NO:
- 25), wherein the polypeptide includes a single mutation of Cys33 selected from the group consisting of Ala33 or Gly33.
1 more element
Dependencies are inferred from the claim text.