Ferritin nanoparticle displaying an HIV trimer
AssigneesInternational AIDS Vaccine Initiative, The Scripps Research Institute, Massachusetts Institute of Technology
InventorsTalar Tokatlian, Benjamin J. Read, Daniel W. Kulp, Sergey Menis, Jon M. Steichen, William R. Schief, Darrell J. Irvine
Life of this patent
Estimating the term…
Abstract
The present invention relates to glycosylate HIV timer nanoparticles fused to self-assembling ferritin proteins which may be utilized as immunogens to enhance trafficking to lymph nodes and germinal centers and to heighten immune responses.
Claims22
A synthetic peptide which comprises a glycosylated Env peptide of HIV and a support peptide, wherein the synthetic peptide forms a self-assembling nanoparticle, wherein the nanoparticle is transported to the follicular dendritic cell (FDC) network and by complement-dependent, mannose-binding-lectin (MBL)-dependent, and/or immunogen-glycan-dependent transport to germinal centers,
- wherein the synthetic peptide has the sequence of BG505_MD39_G41_2JD6 (SEQ ID NO:2), BG505_MD39_link14_2JD6 (SEQ ID NO:
- 3), or BG505_MD39_3bve_m (SEQ ID NO:4),
- wherein the Env peptide is glycosylated with oligomannose, and
- wherein the support peptide is a ferritin based support peptide.
Dependencies are inferred from the claim text.