Cyclic peptide useful in the treatment of cancer
AssigneeSyntherix Limited
InventorHilmar M. Warenius
Life of this patent
Estimating the term…
Abstract
The present invention relates to a cyclic peptide comprising an active region comprising the amino acid sequence X1X2X3X4X5X6 or a salt, derivative, prodrug or mimetic thereof. X2 and X5 are arginine; and either: X1 is (7-methoxy-coumarin-4-yl)-Ala-OH (Dac) and X3, X4 and X6 are any amino acid; or X3 is sarcosine (Sar) and X1, X4 and X6 are any amino acid; or X4 is 5,5-dimethylproline (dmPro) or 3-amino-3-(2-naphthyl)propionic acid (Nap) and X1, X3 and X6 are any amino acid; or X6 is Nap and X1, X3 and X4 are any amino acid. The present invention further relates to a pharmaceutical composition comprising the cyclic peptide and the peptide for use in medicine, and particularly cancer.
Claims14
A cyclic peptide comprising an active region which comprises the amino acid sequence X1X2X3X4X5X6 or a salt thereof, wherein:
- X2 and X5 are arginine;
- and
- wherein:
- X1 is (7-methoxy-coumarin-4-yl)-Ala-OH (Dac), X3 is any non-polar amino acid, and X4 and X6 are any non-polar amino acid selected from Dac, sarcosine (Sar), 3-amino-3-(2-naphthyl)propionic acid (Nap), and 5,5-dimethylproline (dmPro),
- wherein the active region is 6 to 10 amino acids in length.
Dependencies are inferred from the claim text.