Method for increasing bulk density of nicotinamide mononucleotide crystal and crystal thereof

Abstract

The present disclosure provides a method for increasing the bulk density of a nicotinamide mononucleotide crystal and a crystal thereof. The method includes: dissolving nicotinamide mononucleotide in water to obtain an aqueous solution of nicotinamide mononucleotide; performing vacuum concentration or freeze drying on the aqueous solution of nicotinamide mononucleotide to obtain a semi-solid with a water content equal to or less than 15%; adding a solventing-out agent dropwise to the semi-solid under stirring, and meanwhile, performing cooling at a rate of 1-15° C./h to a crystallization end temperature of 5-18° C.; and after a crystal is completely precipitated, performing filtration and drying on the crystal to obtain a nicotinamide mononucleotide crystal with increased bulk density. An NMN crystal of a bulk structure can be prepared by the method, and compared with existing NMN crystals, the bulk density of the NMN crystal is doubled.

Dependencies are inferred from the claim text.