Isoform-specific aldehyde dehydrogenase inhibitors
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsJames Kenneth Chen, Zhiping Feng, Marisa E. Hom, Toni Kline, Cody R. Marshall, Alison E. Ondrus
Life of this patent
Estimating the term…
Abstract
Compounds and methods are provided for inhibiting an aldehyde dehydrogenase (ALDH). Methods of treating cancer are also provided. The ALDH-inhibitor can be a compound that is based on a cyclic guanidine, or an imidazolium core. In certain embodiments, the ALDH-inhibitor compound is a substituted cyclic guanidine, or a substituted imidazolium compound. Aspects of the methods include methods of selectively inhibiting a particular ALDH family member. In some cases, the subject compounds are ALDH1B1-selective inhibitors. In some cases, the subject compounds are ALDH1A3-selective inhibitors.
Claims19
A compound of the formula (II):
- wherein:
- each ------ represents a C—C bond, wherein one or more of the C—C bonds is optionally unsaturated;
- R1 and R3 are each independently selected from aryl, substituted aryl;
- R2 is selected from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, halogen, hydroxyl, acyl, substituted acyl, carboxy, substituted carboxy, amino, substituted amino, aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl;
- R4 is an optional substituent selected from alkyl, substituted alkyl, hydroxy, carbonyl, amino, substituted amino, halogen, nitrile, nitro, acyl, substituted acyl, carboxy, and substituted carboxy;
- n is an integer from 0 to 10;
- and
- m is an integer from 0 to 2, wherein if m is 0, then n is an integer from 0 to 6, and if m is 1, then n is an integer from 0 to 8;
- or
- or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
Dependencies are inferred from the claim text.