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US 12,570,620 B2Granted
Covalent inhibitors of creatine kinase (CK) and uses thereof for treating and preventing cancer
AssigneeDana-Farber Cancer Institute, Inc.
InventorsNathanael S. Gray, Edward Chouchani, Tinghu Zhang, Narek Darabedian, Wenzhi Ji, Jianwei Che
Life of this patent
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Abstract
The present disclosure relates to compounds that are capable of inhibiting creatine kinase. The present disclosure also relates to methods of treating cancer, such as hematological malignancies.
Claims12
A compound of Formula IV or V:
- or a pharmaceutically acceptable salt thereof, wherein
- R4 is alkyl, alkenyl, alkynyl, halo, hydroxyl, carboxyl, acyl, acetyl, ester, thioester, alkoxy, phosphoryl, amino, amide, cyano, nitro, azido, alkylthio, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, heteroaralkyl, sulfonamide, aryl, heteroaryl, heterocyclyl, or aralkyl;
- R5A and R5B are each independently selected from hydrogen, alkyl, alkenyl, alkynyl, hydroxyl, carboxyl, acyl, acetyl, ester, thioester, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, heteroaralkyl, aryl, heteroaryl, heterocyclyl, and aralkyl;
- n=0-4;
- such that when n=0, then:
- a) one of R5A and R5B in Formula IV are selected from alkyl, alkenyl, alkynyl, hydroxyl, carboxyl, acyl, acetyl, ester, thioester, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, heteroaralkyl, aryl, heteroaryl, heterocyclyl, and aralkyl;
- and
- b) R5A and R5B in Formula V are independently selected from alkyl, alkenyl, alkynyl, hydroxyl, carboxyl, acyl, acetyl, ester, thioester, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, heteroaralkyl, aryl, heteroaryl, heterocyclyl, and aralkyl.
5 more elements
Dependencies are inferred from the claim text.