US 12,570,618 B2 · Compound, production method therefor, and pharmaceutical composition

Abstract

A compound represented by formula (1) below, useful for treating cancer. In the formula, R1 and R3-R8 each independently represents a hydrogen atom or an alkyl group, R2 represents a hydrogen atom or a group represented by —ORa, R9 represents a group represented by —C(O)NReRf, Ra, Re, and Rf each independently represents a hydrogen atom, an arylalkyl group that may have a substituent, or a heteroarylalkyl group. A production method that enables the compound to be produced with high efficiency, and a pharmaceutical composition containing the compound as an active ingredient

Claims7

Dependent claims

A compound represented by formula (1) below:

wherein R1 and R3 to R8 each independently represents a hydrogen atom or an alkyl group;
R2 represents a hydrogen atom, or a group represented by —ORa or —NRbRc;
R9 represents a group represented by —CH2ORd, —C(O)ORd, —C(O)R4, —CH2NReRf, or —C(O)NReRf;
and Ra to Rf each independently represents a hydrogen atom, an alkyl group, an aryl group optionally having a substituent, a heteroaryl group optionally having a substituent, an arylalkyl group optionally having a substituent, or a heteroarylalkyl group optionally having a substituent.

1 more element

A method for producing a compound represented by formula (1) below:

wherein R1 and R3 to R8 each independently represents a hydrogen atom or an alkyl group;
R2 represents a hydrogen atom, or a group represented by —ORa or —NRbRc;
R9 represents a group represented by —CH2ORd, —C(O)ORd, —C(O)Rd, —CH2NReRf, or —C(O)NReRf;
and Ra to Rf each independently represents a hydrogen atom, an alkyl group, an aryl group optionally having a substituent, a heteroaryl group optionally having a substituent, an arylalkyl group optionally having a substituent, or a heteroarylalkyl group optionally having a substituent,
the method comprising converting a compound represented by formula (3) below into a compound represented by formula (1):
wherein R1 and R3 to R8 are as described above;
and Z represents a protecting group for a hydroxy group.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/263,513Filed 28 Jan 2022

Priority

JP 2021-02020710 Feb 2021

Published

US 2024/0140918 A12 May 2024

Granted

10 Mar 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

C07D 263/32
Having two or three double bonds between ring members or between ring members and non-ring members: with only hydrogen atoms, hydrocarbon or…
C07F 7/1892
Preparation; Treatments not provided for in C07F7/20: by reactions not provided for in C07F7/1876 - C07F7/1888
A61P 35/00
Antineoplastic agents
C07D 213/30
Radicals substituted by singly-bound oxygen or sulphur atoms: oxygen atoms

Compound, production method therefor, and pharmaceutical composition

Life of this patent

Compound, production method therefor, and pharmaceutical composition

Life of this patent

Abstract

Claims7