Systems and methods for use in dispensing biopharmaceutical materials
AssigneeRegeneron Pharmaceuticals, Inc.
InventorTikiri Jean Dissanayake
Life of this patent
Estimating the term…
Abstract
A system for dispensing biopharmaceutical materials, the system including: a plurality of containers, wherein each of the plurality of containers comprises a screw-on cap having a low temperature silicone stopper; a distribution manifold connected to the plurality of containers, wherein the distribution manifold comprises a plurality of distribution conduits and a plurality of discharge conduits and wherein the distribution conduits and the discharge conduits are in fluid communication with each other; a bulk reservoir for holding the biopharmaceutical materials; and a filter assembly positioned between the bulk reservoir and the distribution manifold.
Claims22
A system for dispensing biopharmaceutical materials, the system comprising:
- a plurality of containers, wherein each of the plurality of containers comprises a screw-on cap having a low temperature silicone stopper;
- a distribution manifold connected to the plurality of containers, wherein the distribution manifold comprises a plurality of distribution conduits and a plurality of discharge conduits, and wherein the distribution conduits and the discharge conduits are in fluid communication with each other;
- a filter assembly fluidly coupled to the distribution manifold;
- and
- an intake conduit positioned downstream of the filter assembly and upstream from the distribution manifold, wherein the filter assembly and the intake conduit are laterally offset from the distribution manifold and the plurality of containers;
- wherein the distribution manifold is arranged via a plurality of rows that each extends parallel to one another and laterally away from the intake conduit;
- and
- wherein each of the plurality of distribution conduits is positioned above the plurality of discharge conduits and aligned along one of the plurality of rows with each of the plurality of rows extending across the plurality of containers that are fluidly coupled to a corresponding distribution conduit of the plurality of distribution conduits.
A plurality of receiving containers for storing biopharmaceutical materials at low temperatures, each of the receiving containers comprising:
- a cap configured to screw onto a neck of the receiving container, wherein the cap comprises one or more openings that enable connection of one or more tubes to an interior of the receiving container;
- a low-temperature silicone stopper positioned in a hollowed out portion of the cap, wherein the low-temperature silicone stopper surrounds the one or more tubes within the interior of the cap;
- and
- a sampling container conduit configured to distribute a portion of the biopharmaceutical material to a sampling container, wherein the sampling container conduit is fluidly connected to the intake conduit via a cross connector and wherein the cross connector forms a direct fluid connection with a plurality of feeder conduits and a distribution conduit;
- wherein the plurality of receiving containers are surrounded by a tube wrap that is configured to collectively contain and support the plurality of receiving containers.
A method for dispensing biopharmaceutical materials, the method comprising:
- flowing the biopharmaceutical materials from a bulk reservoir storing the biopharmaceutical materials through a filter assembly and an intake conduit to a manifold coupled to a plurality of receiving containers, wherein the filter assembly and the intake conduit are laterally offset from the manifold and the plurality of receiving containers;
- and
- supporting a plurality of distribution conduits of the manifold by a plurality of discharge conduits of the manifold, wherein a terminal end of each of the plurality of discharge conduits is passed through a cap of one of the plurality of receiving containers, and wherein a low temperature silicone stopper is integrated into the cap and surrounds the discharge conduit;
- wherein the manifold is arranged via a plurality of rows that each extends parallel to one another and laterally away from the intake conduit;
- and
- wherein each of the plurality of distribution conduits is positioned above the plurality of discharge conduits and aligned along one of the plurality of rows with each of the plurality of rows extending across the plurality of receiving containers that are fluidly coupled to a corresponding distribution conduit of the plurality of distribution conduits.
Dependencies are inferred from the claim text.