Proteins with cardioprotective activity
AssigneeInternational Centre for Genetic Engineering and Biotechnology (Icgeb)
InventorsMauro Giacca, Giulia Ruozi, Francesca Bortolotti
Life of this patent
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Abstract
A protein selected from the group consisting of Chrdl1, Fam3c, Fam3b and a fragment thereof, or a polynucleotide encoding therefor, for use in treating or reducing the risk of heart disease.
Claims40
A method for treating myocardial infarction, wherein the method comprises administering a polypeptide comprising the Fam3b amino acid sequence of SEQ ID NO:
- 3, or a polynucleotide that comprises a nucleotide sequence encoding said polypeptide, to a subject after myocardial infarction.
A method for treating myocardial infarction, wherein the method comprises administering a vector comprising a polynucleotide that comprises a nucleotide sequence encoding a polypeptide comprising the Fam3b amino acid sequence of SEQ ID NO:
- 3, to a subject after myocardial infarction.
A method for treating myocardial infarction, wherein the method comprises administering a pharmaceutical composition, to a subject after myocardial infarction, wherein the pharmaceutical composition comprises a polypeptide comprising the Fam3b amino acid sequence of SEQ ID NO:
- 3, or a vector comprising a polynucleotide that comprises a nucleotide sequence encoding a polypeptide comprising the Fam3b amino acid sequence of SEQ ID NO:
- 3, and a pharmaceutically acceptable vehicle and/or excipient.
A method for treating myocardial infarction, wherein the method comprises administering a protein comprising the amino acid sequence of SEQ ID NO:
- 3 or SEQ ID NO:
- 7, or a polynucleotide that comprises a nucleotide sequence encoding said protein, to a subject after myocardial infarction.
A method for preserving cardiac function and/or reducing fibrosis after myocardial infarction or cardiac toxic damage, wherein the method comprises administering a polypeptide comprising the Fam3b amino acid sequence of SEQ ID NO:
- 3, or a polynucleotide that comprises a nucleotide sequence encoding said polypeptide, to a subject after myocardial infarction or cardiac toxic damage.
A method for preserving cardiac function and/or reducing fibrosis after myocardial infarction or cardiac toxic damage, wherein the method comprises administering a protein comprising the amino acid sequence of SEQ ID NO:
- 3 or SEQ ID NO:
- 7, or a polynucleotide that comprises a nucleotide sequence encoding said protein, to a subject after myocardial infarction or cardiac toxic damage.
Dependencies are inferred from the claim text.