Compositions and methods for the treatment of viral infections

A method for the treatment of a subject having an influenza infection or presumed to have an influenza infection, the method comprising administering to the subject an effective amount of a conjugate described by formula (D-I):

• wherein each of A1 and A2 is zanamivir;
• E comprises an Fc domain monomer comprising an amino acid sequence of SEQ ID NO:
• 63, 64, 67, or 68, wherein each Fc domain optionally lacks C-terminal Lys447;
• L is a linker covalently attached to each of A1, A2, and E, wherein L is covalently attached to each of A1 and A2 independently at position C7 or position C9 of zanamivir;
• n is 1 or 2;
• and
• T is the number of A1-L-A2 moieties conjugated to each E and each T is, independently, an integer from 1 to 20;
• or a pharmaceutically acceptable salt thereof.