Targeting moDC to enhance vaccine efficacy on mucosal surface
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsLei Jin, Samira Mansouri
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Abstract
Described herein are novel vaccine compositions and methods for use thereof in inducing an immune response in a subject especially aged subjects. Specifically exemplified are vaccine compositions that include an antigen; a cyclic dinucleotide; soluble tumor necrosis factor (TNF); or a CD64 antibody or antibody fragment. Optionally, the vaccine composition comprises a TNF conjugated with a moDC targeting moiety in addition to or in place of TNF or CD64 antibody or antibody fragment, or both TNF and CD64 antibody or antibody fragment.
Claims18
A vaccine composition comprising a therapeutically effective amount of
- an antigen;
- a cyclic dinucleotide;
- and
- tumor necrosis factor (TNF) conjugated with a moDC targeting moiety;
- and, optionally, a CD64 antibody or antibody fragment;
- wherein the antigen comprises H7HA, H7N7, PspA, influenza nucleoprotein (NP), HIVenvV1V2 or HIV-1pr55Gag.
An adjuvant composition comprising TNF conjugated with an moDC targeting moiety.
Dependencies are inferred from the claim text.