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US 12,569,555 B2Granted
Organically modified mineral micro-particles, methods of preparing the same and uses thereof
AssigneeCroda International PLC
InventorsLaurent Duroux, Erik Lindblad
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Abstract
The present invention is situated in the field of mineral micro-particles selected from the list consisting of aluminum hydroxide, aluminum phosphate, amorphous aluminium hydroxyphosphate and calcium phosphate micro-particles. More particularly, the invention provides organically-derivatized mineral micro-particles, uses thereof, and methods of preparing the same.
Claims10
Organically-derivatized mineral micro-particles comprising mineral micro-particles derivatized by one or more organic polyphosphates,
- wherein the mineral micro-particles are selected from aluminum phosphate and amorphous aluminum hydroxyphosphate micro-particles having a size in a range from 0.01 μm to 10 μm,
- wherein the one or more organic polyphosphates is selected from compounds of formula 1A or 1B
- wherein:
- n is an integer in the range of 1-5;
- m is an integer in the range of 2-10;
- Ra denotes adenosine;
- and
- Rb denotes organic substituents selected from inositols and other cyclitols,
- wherein a stoichiometric ratio of aluminum (Al) to phosphorus (P) is 1.2+/−0.15 to 1, and
- wherein an antigen is adsorbed on a surface of at least a portion of the organically-derivatized mineral-microparticles.
7 more elements
Dependencies are inferred from the claim text.