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US 12,569,554 B2Granted
Triterpene saponin analogues
AssigneesAdjuvance Technologies, Inc., Memorial Sloan Kettering Cancer Center
InventorsPhilip Livingston, Govind Ragupathi, Jeffrey Gardner, J Tyler Martin
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Abstract
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
Claims18
A pharmaceutical formulation comprising a compound that is
- or a pharmaceutically acceptable salt thereof,
- wherein the pharmaceutical formulation contains unicellular liposomal vesicles containing the compound, wherein the unicellular liposomal vesicles are formed by combining a lipid and an alcohol in the presence of the compound, and wherein the lipid is cholesterol.
A method of preparing a pharmaceutical formulation comprising a compound that is
- or a pharmaceutically acceptable salt thereof, the method comprising:
- forming unicellular liposomal vesicles in the presence of the compound.
Dependencies are inferred from the claim text.