RNA construct
AssigneeImperial College Innovations Limited
InventorsRobin Shattock, Anna Blakney, Paul McKay
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Abstract
The invention relates to RNA constructs encoding (i) at least one therapeutic biomolecule; and (ii) at least one innate inhibitor protein (IIP). The constructs are RNA replicons and saRNA molecules, and the invention includes genetic constructs or vectors encoding such RNA replicons. The invention extends to the use of such RNA constructs and replicons in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.
Claims24
An RNA construct encoding (i) at least one therapeutic biomolecule;
- and (ii) at least one innate inhibitor protein (IIP), wherein the RNA construct comprises or is derived from a virus selected from the group of species consisting of:
- Venezuelan Equine Encephalitis Virus (VEEV);
- enterovirus 71;
- Encephalomyocarditis virus;
- Kunjin virus;
- and Middle East respiratory syndrome virus.
Dependencies are inferred from the claim text.