Stem cells for transplantation and manufacturing method therefor
AssigneeNational Center of Neurology and Psychiatry
InventorsTakashi Okada, Yuko Kasahara, Shinichi Takeda
Life of this patent
Estimating the term…
Abstract
It is intended to provide MSCs for transplantation that have an improved post-transplantation cell survival rate and engraftment rate and are highly safe with fewer adverse reactions, and a method for conveniently producing MSCs for transplantation having a high cell survival rate and engraftment rate. As means therefor, the present invention provides a stem cell for transplantation comprising an MSC capable of overexpressing IL-10.
Claims6
A method for inducing acquired immunological tolerance in a subject to an immunogen, wherein the immunogen is an AAV9 vector, the method comprising:
- a first step of administering systemically to the subject a human mesenchymal stem cell (hMSC) and the immunogen, wherein the hMSC is administered on the day before or the very day of administering the immunogen;
- and, after a predetermined number of days,
- a second step of administering systemically to the subject a human MSC and the immunogen, wherein a hMSC is administered on the day before or the very day of administering the immunogen,
- whereby an immune response to the immunogen in the subject is suppressed.
Dependencies are inferred from the claim text.