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US 12,569,538 B2Granted
DPEP-1 binding compositions and methods of use
AssigneeArch Biopartners, Inc.
InventorsStephen Mark Robbins, Donna Lorraine Senger, Jennifer Joy Rahn, Arthur Wing Sze Lau, Daniel Abraham Muruve, Saurav Roy Choudhury, Liane Babes, Paul Kubes
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Abstract
Pharmaceutical compositions and methods of their use are provided for reducing inflammation in a subject, blocking leukocyte recruitment, inhibiting tumor metastasis, treating sepsis and preventing/reducing acute kidney injury.
Claims13
A method for treating inflammation or blocking leucocyte recruitment in a subject in need thereof, comprising administering an effective amount of a compound that binds to DPEP-1 to the subject, thereby treating inflammation or blocking leucocyte recruitment;
- wherein the compound that binds to DPEP-1 is selected from the group consisting of:
- (a) cilastatin;
- (b) a peptide that comprises a GFE tripeptide sequence selected from CGFECVRQCPERC (GFE-1) or CGFELETC (GFE-2);
- (c) a compound that comprises a blocking antibody of DPEP-1;
- and
- (d) a compound that comprises an aminophosphinic acid derivative having the formula:
- wherein X is selected from the group consisting of any halogen or C1 to C6 haloalkyl or C1 to C6 di- or trihaloalkyl or C1 to C6 alkyl, NH2, N(C1 to C6 alkyl)2, and NH(C1 to C6 alkyl), CF3NR′, or F, Cl, Br, I125, I, CF3NR′;
- Y is selected from the group consisting of any halogen, H, CH3, OCH3, NH2, N(C1 to C6 alkyl)2, and NH(C1 to C6 alkyl), NR′ or C1 to C6 haloalkyl, or C1 to C6 alkoxy group or C1 to C6 di- or trihaloalkyl or C1 to C6 alkyl;
- NR′ is selected from NH2, N(C1 to C6 alkyl)2, and NH(C1 to C6 alkyl);
- and
- Z is selected from O or S.
8 more elements
Dependencies are inferred from the claim text.