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US 12,569,534 B2Granted
Therapeutic nanoparticles by coacervate complexation and their use for treating bacteria
AssigneeAcademia Sinica
InventorsChe-Ming Jack Hu, Yu-Han Liu, Te-Li Chen
Life of this patent
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Abstract
A therapeutic nanoparticle containing a cationic polypeptide and a polyanionic molecule, in which the cationic polypeptide, exerting antibacterial activity, forms electrostatic interaction with the polyanionic molecule, and the therapeutic nanoparticle has diameter of less than 50 mun. Also disclosed are a pharmaceutical composition, a treatment method, and a preparation method, all related to the therapeutic nanoparticle.
Claims8
A therapeutic nanoparticle, comprising:
- a cationic polypeptide,
- a polyanionic molecule, and
- a polyethyleneglycol (PEG) lipid,
- wherein the therapeutic nanoparticle has a hydrodynamic diameter of less than 50 nm,
- wherein the cationic polypeptide is colistin,
- wherein the polyanionic molecule is an anionic polypeptide or an anionic oligonucleotide of less than 500 base pairs;
- wherein the PEG lipid is selected from the group consisting of DSPE-PEG, DSPE-PEG-Maleimide, DSPE-PEG-Biotin, mPEG-Cholesterol, and Cholesterol-PEG-Amine;
- and
- wherein the colistin to polyanionic molecule is present at a charge ratio of 1:4 to 7:1 (cation:anion).
6 more elements
Dependencies are inferred from the claim text.