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US 12,569,530 B2Granted
Tannin-based antiproliferative pharmaceutical
AssigneeImam Abdulrahman Bin Faisal University
InventorsFazil Ahmad, Krishna Mohan Surapaneni, Abeer Mohammed Al-Subaie, Balu Kamaraj
Life of this patent
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Abstract
A pharmaceutical composition comprising a tannin selected from 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-β-D-glucose, 3-O-digalloyl-1,2,4,6-tetra-O-galloyl-β-D-glucose, 6-O-digalloyl-1,2,3,4-tetra-O-galloyl-β-D-glucose, 2,6-bis-O-digalloyl-1,3-di-O-galloyl-β-D-glucose, and 6-O-trigalloyl-1,2,3-tri-O-galloyl-β-D-glucose. The tannin may be derived from Quercus infectoria. The pharmaceutical composition is used in a method of treating cancer, particularly oral cancer.
Claims9
A method for treating an oral cancer in a patient, comprising
- administering to the patient a therapeutically effective amount of a pharmaceutical composition, comprising:
- an active ingredient which is at least one tannin selected from the group consisting of 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-β-D-glucose, 3-O-digalloyl-1,2,4,6-tetra-O-galloyl-β-D-glucose, 6-O-digalloyl-1,2,3,4-tetra-O-galloyl-β-D-glucose, 2,6-bis-O-digalloyl-1,3-di-O-galloyl-β-D-glucose, and 6-O-trigalloyl-1,2,3-tri-O-galloyl-β-D-glucose, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, and
- a pharmaceutically acceptable carrier and/or excipient,
- wherein the active ingredient accounts for greater than 99% of a total weight of tannins present in the pharmaceutical composition.
1 more element
Dependencies are inferred from the claim text.