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US 12,569,521 B2Granted
Methods and compositions for treating inflammatory skin disease with recombinant microorganisms
AssigneeAzitra Inc
InventorTravis Michael Whitfill
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Abstract
The present invention provides isolated plasmids, recombinant microorganisms, kits, and methods for the treatment of inflammatory skin disease.
Claims6
A method of treating an inflammatory skin disease comprising administering to a mammalian subject in need thereof a therapeutically effective amount of a biotherapeutic composition comprising live recombinant Staphylococcus epidermidis comprising an expression vector, wherein the expression vector, or combination of bacteria, wherein the Staphylococcus epidermidis comprises
- (i) a first coding sequence comprising a nucleic acid sequence encoding a filaggrin (FLG) therapeutic polypeptide, wherein the therapeutic polypeptide consists of SEQ ID NO:
- 46;
- (ii) a second coding sequence comprising a nucleic acid sequence encoding a cell penetrating peptide;
- (iii) a third coding sequence comprising a nucleic acid sequence encoding an export signal;
- and
- (iv) a promoter operably linked to the first coding sequence, the second coding sequence and the third coding sequence, wherein the first coding sequence, the second coding sequence and the third-coding sequence,
- wherein the recombinant Staphylococcus epidermidis first coding sequence, the second coding sequence and the third-coding sequence are capable of expresses a filaggrin fusion product comprising the FLG therapeutic polypeptide.
4 more elements
Dependencies are inferred from the claim text.