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US 12,569,517 B2Granted
Method for treating osteoarthritis with mesenchymal stem cell exosomes
AssigneeDirect Biologics, LLC
InventorsKenneth Allen Pettine, Timothy Alexander Moseley
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Abstract
Disclosed herein are methods for treating osteoarthritis may be a one-step arthroscopic procedure and may include detaching synovial mesenchymal stem cells (MSCs) from the synovium using a brush device; covering articular cartilage in an affected joint with a scaffold; and placing concentrated MSC exosomes into the affected joint to stimulate differentiation of synovial MSCs into articular cartilage cells.
Claims20
A method of treating osteoarthritis in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of a mesenchymal stem cell (MSC) exosome composition comprising (i) MSC exosomes;
- (ii) an insulin-like growth factor (IGF) and (iii) vascular endothelial growth factor (VEGF).
Dependencies are inferred from the claim text.