Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsKevin Fitzgerald, Gregory Hinkle
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Abstract
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Patatin-Like Phospholipase Domain Containing 3 (PNPLA3) gene, and methods of using such RNAi agents to inhibit expression of a PNPLA3 gene and methods of treating subjects having Nonalcoholic Fatty Liver Disease (NAFLD) and/or a PNPLA3-associated disorder.
Claims26
A double stranded ribonucleic acid (RNAi) agent, or a salt thereof, for inhibiting expression of Patatin-Like Phospholipase Domain Containing 3 (PNPLA3), wherein said double stranded RNAi agent, or a salt thereof, comprises a sense strand and an antisense strand forming a double stranded region, wherein the antisense strand comprises at least 15 contiguous nucleotides from the nucleotide sequence 5′-UUUGGAAUGGAACUCAGACACCA-3′ of SEQ ID NO:
- 1370 or 5′-UUAAACAUUAUUUUAGUUAGGUG-3′ of SEQ ID NO:
- 1362.
Dependencies are inferred from the claim text.